A pH-sensitive near-infrared fluorescent probe with alkaline pKa for chronic wound monitoring in diabetic mice

Hengtang Mai; Yu Wang; Shuang Li; Ruizhen Jia; Sixian Li; Qian Peng; Yan Xie; Xiang Hu; Song Wu

doi:10.1039/C9CC02289A

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A pH-sensitive near-infrared fluorescent probe with alkaline pK_a for chronic wound monitoring in diabetic mice†

Hengtang Mai,^a Yu Wang,^b Shuang Li,^a Ruizhen Jia,^a Sixian Li,^a Qian Peng,^a Yan Xie,^a Xiang Hu^b and Song Wu

*^a

Author affiliations

* Corresponding authors

^a Hubei Province Engineering and Technology Research Center for Fluorinated Pharmaceuticals, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, P. R. China
E-mail: ws_whu@163.com

^b Department of Orthopaedic Trauma and Microsurgy, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China

Abstract

A pH-sensitive near-infrared fluorescent probe with alkaline pK_a, AlkaP-1, was developed by incorporating a benzoyl hydrazine group into a cyanine dye. The significant fluorescence changes in the alkaline regions enable the probe to monitor the alkalization process from acute wounds to chronic wounds in diabetic mice.

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Article information

DOI: https://doi.org/10.1039/C9CC02289A
Article type: Communication
Submitted: 24 Mar 2019
Accepted: 28 May 2019
First published: 30 May 2019

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Chem. Commun., 2019,55, 7374-7377

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A pH-sensitive near-infrared fluorescent probe with alkaline pK_a for chronic wound monitoring in diabetic mice

H. Mai, Y. Wang, S. Li, R. Jia, S. Li, Q. Peng, Y. Xie, X. Hu and S. Wu, Chem. Commun., 2019, 55, 7374 DOI: 10.1039/C9CC02289A

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Chemical Communications