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Issue 54, 2019
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Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery

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Abstract

We have designed and synthesized a set of cell-penetrating foldamers (CPFs), Blocks 1–8, composed of the common amino acids Leu, Arg, and Gly, as well as the helicogenic amino acid 2-aminoisobutyric acid. The findings showed that Block 3 could deliver siRNA into cells without significant cytotoxicity. We also demonstrated that Block 3 could be applied to selectively kill the oncogene-driven cancer cells.

Graphical abstract: Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery

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Supplementary files

Article information


Submitted
20 Mar 2019
Accepted
30 May 2019
First published
03 Jun 2019

Chem. Commun., 2019,55, 7792-7795
Article type
Communication

Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery

T. Misawa, N. Ohoka, M. Oba, H. Yamashita, M. Tanaka, M. Naito and Y. Demizu, Chem. Commun., 2019, 55, 7792
DOI: 10.1039/C9CC02203A

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