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Issue 34, 2019
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Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

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Abstract

We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.

Graphical abstract: Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

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Publication details

The article was received on 20 Feb 2019, accepted on 05 Mar 2019 and first published on 06 Mar 2019


Article type: Communication
DOI: 10.1039/C9CC01442J
Chem. Commun., 2019,55, 4905-4908

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    Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

    K. Nam, T. Kim, Y. M. Kim, K. Yang, D. Choe, L. B. Mensah, K. Y. Choi and Y. H. Roh, Chem. Commun., 2019, 55, 4905
    DOI: 10.1039/C9CC01442J

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