Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 27, 2019
Previous Article Next Article

Selective amidation by a photocatalyzed umpolung reaction

Author affiliations

Abstract

A metal-catalyzed organic transformation merged with another organophotocatalyst has been developed under mild conditions for production of α-ketoamides. CuI-catalyzed highly selective and rapid COCH2-amidation in the presence of electrophilic Cα[double bond, length as m-dash]O bonds, which is synchronized by an eosin Y (EY)-photocatalyst, furnishes a wide range of labile α-ketoamides, unsymmetrical oxalamides and chiral analogues on the treatment of 1,3-dicarbonyls with amines, PhIO and LED light at room temperature. The current strategy opens up a new avenue to making photocatalysis a common synthetic tool for large-scale production in academia and industry.

Graphical abstract: Selective amidation by a photocatalyzed umpolung reaction

Back to tab navigation

Supplementary files

Article information


Submitted
06 Feb 2019
Accepted
01 Mar 2019
First published
01 Mar 2019

Chem. Commun., 2019,55, 3883-3886
Article type
Communication

Selective amidation by a photocatalyzed umpolung reaction

D. Ghosh, R. Nandi, S. Khamarui, S. Ghosh and D. K. Maiti, Chem. Commun., 2019, 55, 3883
DOI: 10.1039/C9CC01079C

Social activity

Search articles by author

Spotlight

Advertisements