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Issue 31, 2019
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Probing transient non-native states in amyloid beta fiber elongation by NMR

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Abstract

Using NMR to probe transient binding of Aβ1–40 monomers to fibers, we find partially bound conformations with the highest degree of interaction near F19–K28 and a lesser degree of interaction near the C-terminus (L34–G37). This represents a shift away from the KLVFFA recognition sequence (residues 16–21) currently used for inhibitor design.

Graphical abstract: Probing transient non-native states in amyloid beta fiber elongation by NMR

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Publication details

The article was received on 05 Feb 2019, accepted on 18 Mar 2019 and first published on 19 Mar 2019


Article type: Communication
DOI: 10.1039/C9CC01067J
Chem. Commun., 2019,55, 4483-4486

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    Probing transient non-native states in amyloid beta fiber elongation by NMR

    J. R. Brender, A. Ghosh, S. A. Kotler, J. Krishnamoorthy, S. Bera, V. Morris, T. B. Sil, K. Garai, B. Reif, A. Bhunia and A. Ramamoorthy, Chem. Commun., 2019, 55, 4483
    DOI: 10.1039/C9CC01067J

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