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Issue 31, 2019
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Probing transient non-native states in amyloid beta fiber elongation by NMR

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Abstract

Using NMR to probe transient binding of Aβ1–40 monomers to fibers, we find partially bound conformations with the highest degree of interaction near F19–K28 and a lesser degree of interaction near the C-terminus (L34–G37). This represents a shift away from the KLVFFA recognition sequence (residues 16–21) currently used for inhibitor design.

Graphical abstract: Probing transient non-native states in amyloid beta fiber elongation by NMR

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Article information


Submitted
05 Feb 2019
Accepted
18 Mar 2019
First published
19 Mar 2019

Chem. Commun., 2019,55, 4483-4486
Article type
Communication

Probing transient non-native states in amyloid beta fiber elongation by NMR

J. R. Brender, A. Ghosh, S. A. Kotler, J. Krishnamoorthy, S. Bera, V. Morris, T. B. Sil, K. Garai, B. Reif, A. Bhunia and A. Ramamoorthy, Chem. Commun., 2019, 55, 4483
DOI: 10.1039/C9CC01067J

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