Issue 31, 2019
From the journal:

Chemical Communications

A bioluminescent probe for imaging endogenous hydrogen polysulfides in live cells and a murine model of bacterial infection†

Jun-Bin Li,a   Qianqian Wang,a   Hong-Wen Liu, ORCID logo a   Lin Yuan ORCID logo a  and  Xiao-Bing Zhang ORCID logo *a  

* Corresponding authors

a Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
E-mail: xbzhang@hnu.edu.cn

Abstract

In this work, we report the first bioluminescent probe BP-PS for detecting H2Sn with high specificity and sensitivity. Owing to the bioluminescence imaging without requiring an excitation light source, tissue autofluorescence is eliminated and BP-PS shows a high signal-to-noise ratio. Moreover, BP-PS was successfully utilized to visualize endogenous H2Sn in live cells and a murine model of bacterial infection.

Graphical abstract: A bioluminescent probe for imaging endogenous hydrogen polysulfides in live cells and a murine model of bacterial infection

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Article information

DOI
https://doi.org/10.1039/C9CC01699F
Article type
Communication
Submitted
01 Mar 2019
Accepted
18 Mar 2019
First published
18 Mar 2019

Chem. Commun., 2019,55, 4487-4490

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A bioluminescent probe for imaging endogenous hydrogen polysulfides in live cells and a murine model of bacterial infection

J. Li, Q. Wang, H. Liu, L. Yuan and X. Zhang, Chem. Commun., 2019, 55, 4487 DOI: 10.1039/C9CC01699F

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