Enzyme-assisted self-assembly within a hydrogel induced by peptide diffusion

Miryam Criado-Gonzalez; Jennifer Rodon Fores; Déborah Wagner; André Pierre Schröder; Alain Carvalho; Marc Schmutz; Eva Harth; Pierre Schaaf; Loïc Jierry; Fouzia Boulmedais

doi:10.1039/C8CC09437C

Enzyme-assisted self-assembly within a hydrogel induced by peptide diffusion†

Miryam Criado-Gonzalez,

^abc Jennifer Rodon Fores,^a Déborah Wagner,^a André Pierre Schröder,^a Alain Carvalho,^a Marc Schmutz,

^a Eva Harth,

^d Pierre Schaaf,*^abc Loïc Jierry

*^a and Fouzia Boulmedais

*^a

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* Corresponding authors

^a Université de Strasbourg, CNRS, Institut Charles Sadron UPR 22, 67034 Strasbourg, France
E-mail: schaaf@unistra.fr, Loic.Jierry@ics-cnrs.unistra.fr, fouzia.boulmedais@ics-cnrs.unistra.fr

^b Institut National de la Santé et de la Recherche Médicale, UMR-S 1121, “Biomatériaux et Bioingénierie”, 67087 Strasbourg, France

^c Université de Strasbourg, Faculté de Chirurgie Dentaire, Fédération de Médecine Translationnelle de Strasbourg and Fédération des Matériaux et Nanoscience d’Alsace, 67000 Strasbourg, France

^d Department of Chemistry, Center of Excellence in Polymer Chemistry, University of Houston, Houston, Texas 77030, USA

Abstract

The diffusion of adequate peptide through an enzyme-embedded host hydrogel leads to the in situ start-up and growth of an interpenetrated fibrous network. Based on the enzyme-assisted self-assembly concept, both chemistry and mechanical features of the hybrid hydrogel can be tuned.

Chemical Communications

Enzyme-assisted self-assembly within a hydrogel induced by peptide diffusion†

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Enzyme-assisted self-assembly within a hydrogel induced by peptide diffusion

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