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Issue 8, 2019
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New half-sandwich ruthenium(ii) complexes as proteosynthesis inhibitors in cancer cells

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Abstract

Half-sandwich ruthenium(II) complexes [(η6-p-cymene)Ru(C^N)-(X)]0/+ (X = Cl, py or 4-NMe2-py) containing a cyclometalated 2-ppy or 1-ppz with a non-coordinated CHO group as a handle for further functionalization have been synthesized to achieve selective cytotoxicity to cancer cells, the more potent compounds acting as proteosynthesis inhibitors; this is a new mode of action for half-sandwich metal complexes.

Graphical abstract: New half-sandwich ruthenium(ii) complexes as proteosynthesis inhibitors in cancer cells

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Supplementary files

Article information


Submitted
19 Nov 2018
Accepted
04 Jan 2019
First published
04 Jan 2019

Chem. Commun., 2019,55, 1140-1143
Article type
Communication

New half-sandwich ruthenium(II) complexes as proteosynthesis inhibitors in cancer cells

F. J. Ballester, E. Ortega, V. Porto, H. Kostrhunova, N. Davila-Ferreira, D. Bautista, V. Brabec, F. Domínguez, M. D. Santana and J. Ruiz, Chem. Commun., 2019, 55, 1140
DOI: 10.1039/C8CC09211G

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