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Issue 8, 2019
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Rhodium(iii)-catalyzed regioselective oxidative annulation of anilines and allylbenzenes via C(sp3)–H/C(sp2)–H bond cleavage

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Abstract

Described herein is the merging of allylic C(sp3)–H activation and directed C(sp2)–H activation into a single approach for discovering unprecedented chemical transformations. As a proof-of-concept, we disclose for the first time the rhodium-catalyzed regioselective oxidative annulation of anilines with allylbenzenes to deliver a variety of indoles. In this work, the C3 and C2 positions of the allylic segment are set to construct C–N and C–C bonds, respectively.

Graphical abstract: Rhodium(iii)-catalyzed regioselective oxidative annulation of anilines and allylbenzenes via C(sp3)–H/C(sp2)–H bond cleavage

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Publication details

The article was received on 16 Nov 2018, accepted on 20 Dec 2018 and first published on 20 Dec 2018


Article type: Communication
DOI: 10.1039/C8CC09099H
Chem. Commun., 2019,55, 1068-1071

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    Rhodium(III)-catalyzed regioselective oxidative annulation of anilines and allylbenzenes via C(sp3)–H/C(sp2)–H bond cleavage

    Y. Liu, Y. Yang, C. Wang, Z. Wang and J. You, Chem. Commun., 2019, 55, 1068
    DOI: 10.1039/C8CC09099H

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