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Tunable Fabrication of a New Theranostic Fe3O4-black TiO2 Nanocomposites: Dual Wavelength Stimulated Synergistic Imaging-guided Phototherapy in Cancer

Abstract

The development of a simplified theranostic system with high-efficiency for multifunctional imaging-guided photodynamic therapy/ photothermal therapy/ (PDT/PTT) is a great challenge. Therefore, a versatile fabrication strategy is introduced to design new Fe3O4-black TiO2 nanocomposites (Fe-Ti NCs). The Fe-Ti NCs exhibit an intense broad light absorption band, high photothermal conversion efficiency, inherited phototherapy, and magnetic resonance imaging (MRI) properties. The in vitro results demonstrate synergistic PTT and PDT capability under 808 nm at low concentration and power density. Fe-Ti NCs also show superior phototherapy performance (PTT/PDT) under 671 nm laser. The confocal microscopy analysis demonstrates ROS-mediated synergistic phototherapy. Hematological and histological analysis confirms no obvious toxicity of Fe-Ti NCs. In vivo photoinduced tumor ablation capability is assessed and monitored the rapid increase in temperature (60±2°C) after being exposed to 808 nm laser at 0.7 W cm–2 for 5 min. Then, the same change in temperature is observed under 671 nm laser at 0.5 W cm–2. Thus, in vitro and in vivo dual-wavelength laser tumor ablation ability of Fe-Ti NCs verified excellent synergistic phototherapy efficacy against tumors. Moreover, Fe-Ti NCs exhibit superparamagnetic behavior, high magnetization value (48 emug−1), good r2 relaxivity value (38.2 mM −1 s −1), and excellent T2 imaging capability to monitor therapeutic performance.

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Publication details

The article was received on 14 Oct 2018, accepted on 25 Nov 2018 and first published on 26 Nov 2018


Article type: Paper
DOI: 10.1039/C8TB02704H
Citation: J. Mater. Chem. B, 2018, Accepted Manuscript
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    Tunable Fabrication of a New Theranostic Fe3O4-black TiO2 Nanocomposites: Dual Wavelength Stimulated Synergistic Imaging-guided Phototherapy in Cancer

    M. Saeed, M. Z. Iqbal, W. Ren, Y. Xia, W. S. Khan and A. Wu, J. Mater. Chem. B, 2018, Accepted Manuscript , DOI: 10.1039/C8TB02704H

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