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Issue 45, 2018
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Precise supramolecular control of surface coverage densities on polymer micro- and nanoparticles

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Abstract

We report herein the controlled surface functionalization of micro- and nanoparticles by supramolecular host–guest interactions. Our idea is to exploit the competition of two high-affinity guests for binding to the surface-bound supramolecular host cucurbit[7]uril (CB7). To establish our strategy, surface azide groups were introduced to hard-sphere (poly)methylmethacrylate particles with a grafted layer of poly(acrylic acid), and a propargyl derivative of CB7 was coupled to the surface by click chemistry. The amount of surface-bound CB7 was quantified with the high-affinity guest aminomethyladamantane (AMADA), which revealed CB7 surface coverage densities around 0.3 nmol cm−2 indicative of a 3D layer of CB7 binding sites on the surface. The potential for surface functionalization was demonstrated with an aminoadamantane-labeled rhodamine (Ada-Rho) as a second high-affinity guest. Simultaneous incubation of CB7-functionalized particles with both high-affinity guests, AMADA and Ada-Rho, revealed a simple linear relationship between the resulting surface coverage densities of the model fluorescent dye and the mole fraction of Ada-Rho in the incubation mixture. This suggests a highly modular supramolecular strategy for the stable immobilization of application-relevant molecules on particle surfaces and a precise control of their surface coverage densities.

Graphical abstract: Precise supramolecular control of surface coverage densities on polymer micro- and nanoparticles

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Publication details

The article was received on 16 Jul 2018, accepted on 17 Sep 2018 and first published on 18 Sep 2018


Article type: Edge Article
DOI: 10.1039/C8SC03150A
Citation: Chem. Sci., 2018,9, 8575-8581
  • Open access: Creative Commons BY-NC license
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    Precise supramolecular control of surface coverage densities on polymer micro- and nanoparticles

    S. Zhang, Z. Domínguez, K. I. Assaf, M. Nilam, T. Thiele, U. Pischel, U. Schedler, W. M. Nau and A. Hennig, Chem. Sci., 2018, 9, 8575
    DOI: 10.1039/C8SC03150A

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