The synthesis of imidazo[1,5-a]quinolines via a decarboxylative cyclization under metal-free conditions

Zicong Yan; Changfeng Wan; Yu Yang; Zhenggen Zha; Zhiyong Wang

doi:10.1039/C8RA03786H

The synthesis of imidazo[1,5-a]quinolines via a decarboxylative cyclization under metal-free conditions†

Zicong Yan,^a Changfeng Wan,^b Yu Yang,^a Zhenggen Zha*^a and Zhiyong Wang

*^a

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* Corresponding authors

^a Hefei National Laboratory for Physical Sciences at Microscale, CAS Key Laboratory of Soft Matter Chemistry & Center for Excellence in Molecular Synthesis of Chinese Academy of Sciences, Collaborative Innovation Center of Suzhou Nano Science and Technology & School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui, P. R. China
E-mail: zwang3@ustc.edu.cn
Tel: +86-551-6360-3185

^b College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, P. R. China
E-mail: wanfeng@jxnu.edu.cn

Abstract

An iodine-mediated decarboxylative cyclization was developed from α-amino acids and 2-methyl quinolines under metal-free conditions, affording a variety of imidazo[1,5-a]quinolines with moderate to good yields.

This article is part of the themed collection: Editors' Collection: Greener synthetic approaches towards quinoline derivatives

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DOI: https://doi.org/10.1039/C8RA03786H
Article type: Paper
Submitted: 03 May 2018
Accepted: 15 Jun 2018
First published: 25 Jun 2018
This article is Open Access

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RSC Adv., 2018,8, 23058-23065

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The synthesis of imidazo[1,5-a]quinolines via a decarboxylative cyclization under metal-free conditions

Z. Yan, C. Wan, Y. Yang, Z. Zha and Z. Wang, RSC Adv., 2018, 8, 23058 DOI: 10.1039/C8RA03786H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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The synthesis of imidazo[1,5-a]quinolines via a decarboxylative cyclization under metal-free conditions†

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The synthesis of imidazo[1,5-a]quinolines via a decarboxylative cyclization under metal-free conditions

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