Metal-free heterogeneous and mesoporous biogenic graphene-oxide nanoparticle-catalyzed synthesis of bioactive benzylpyrazolyl coumarin derivatives

T. A. J. Siddiqui; Balaji G. Ghule; Shoyebmohamad Shaikh; Pritamkumar V. Shinde; Krishna Chaitanya Gunturu; P. K. Zubaidha; Je Moon Yun; Colm O'Dwyer; Rajaram S. Mane; Kwang Ho Kim

doi:10.1039/C7RA12550J

Metal-free heterogeneous and mesoporous biogenic graphene-oxide nanoparticle-catalyzed synthesis of bioactive benzylpyrazolyl coumarin derivatives†

T. A. J. Siddiqui,^a Balaji G. Ghule,

^b Shoyebmohamad Shaikh,^b Pritamkumar V. Shinde,

^b Krishna Chaitanya Gunturu,^a P. K. Zubaidha,^a Je Moon Yun,

^c Colm O'Dwyer,

*^de Rajaram S. Mane

*^bc and Kwang Ho Kim

*^c

Author affiliations

* Corresponding authors

^a School of Chemical Sciences, SRTM University, Nanded, India-431606

^b Center for Nanomaterials & Energy Devices, School of Physical Sciences, SRTM University, Nanded, India-431606
E-mail: rajarammane70@srtmun.ac.in

^c Global Frontier R&D Center for Hybrid Interface Materials, Pusan National University, San 30 Jangjeon-dong, Geumjeong-gu, Busan, Republic of Korea
E-mail: kwhokim@pusan.ac.kr

^d School of Chemistry, University College Cork, Cork T12 YN60, Ireland
E-mail: c.odwyer@ucc.ie

^e Micro-nano Systems Centre, Tyndall National Institute, Lee Maltings, Cork T12 R5CP, Ireland

Abstract

We report the preparation of graphene oxide nanoparticles (GONPs), a metal-free, heterogeneous, non-toxic, reusable and mesoporous green-(acid)-catalyst obtained by sugar carbonization through a micro-wave chemical synthesis method for the synthesis of bio-active benzylpyrazolyl coumarin derivatives (BCDs) under thermal conditions (50 °C) in ethanol solvent. The obtained products were purified by re-crystallization from ethanol, assuring usability of GONPs in multicomponent reactions (MCRs) that could find wide application in the synthesis of a variety of biologically potent molecules of therapeutic significance.

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Metal-free heterogeneous and mesoporous biogenic graphene-oxide nanoparticle-catalyzed synthesis of bioactive benzylpyrazolyl coumarin derivatives†

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