Jump to main content
Jump to site search


Copper-catalyzed oxidative coupling of quinoxalin-2(1H)-ones with alcohols: access to hydroxyalkylation of quinoxalin-2(1H)-ones

Author affiliations

Abstract

An efficient copper-catalyzed protocol for the synthesis of hydroxyl-containing quinoxalin-2(1H)-ones from the radical reaction of quinoxalin-2(1H)-ones with alcohols was developed with moderate to good yields. Quinoxalin-2(1H)-ones were coupled with alkyl radicals through direct catalytic functionalization of the α sp3 C–H bond of alcohols. The methodology demonstrates a broad substrate scope, excellent functional group tolerance, high atom economy and high efficiency, thus enabling the preparation of diverse potentially valuable hydroxyl-containing quinoxalin-2(1H)-ones.

Graphical abstract: Copper-catalyzed oxidative coupling of quinoxalin-2(1H)-ones with alcohols: access to hydroxyalkylation of quinoxalin-2(1H)-ones

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Sep 2018, accepted on 11 Oct 2018 and first published on 12 Oct 2018


Article type: Research Article
DOI: 10.1039/C8QO00979A
Citation: Org. Chem. Front., 2018, Advance Article
  •   Request permissions

    Copper-catalyzed oxidative coupling of quinoxalin-2(1H)-ones with alcohols: access to hydroxyalkylation of quinoxalin-2(1H)-ones

    J. Fu, J. Yuan, Y. Zhang, Y. Xiao, P. Mao, X. Diao and L. Qu, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO00979A

Search articles by author

Spotlight

Advertisements