Reusable Fe2O3-nanoparticle catalysed efficient and selective hydroboration of carbonyl compounds

Abstract

The first Fe₂O₃-nanoparticle catalysed hydroboration of aromatic and aliphatic aldehydes and ketones with HBpin (pin = OCMe₂CMe₂O) is reported. The reaction proceeds under mild conditions (room temperature) and is moderately sensitive to air. This process is applicable to a broad range of substrates with high functional group compatibility. Moreover, aldehydes are selectively hydroborated over other reducible functional groups, such as ketone, nitrile, hydroxide, alkene, amide, ester, nitro and halide groups.