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Iron-catalyzed alkynylation of tertiary aliphatic amines with 1-iodoalkynes to synthesize propargylamines

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Abstract

A method of alkynylation of tertiary aliphatic amines with 1-iodoalkynes has been developed in the presence of FeCl2 as a catalyst and tert-butyl hydroperoxide as an oxidant. With this method, a variety of propargylamines were obtained in good to excellent yields from inexpensive and readily available reagents. The studies on the possible reaction pathway suggest that this reaction proceeds through a radical process.

Graphical abstract: Iron-catalyzed alkynylation of tertiary aliphatic amines with 1-iodoalkynes to synthesize propargylamines

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Publication details

The article was received on 23 Sep 2018, accepted on 24 Oct 2018 and first published on 25 Oct 2018


Article type: Research Article
DOI: 10.1039/C8QO01028E
Citation: Org. Chem. Front., 2018, Advance Article
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    Iron-catalyzed alkynylation of tertiary aliphatic amines with 1-iodoalkynes to synthesize propargylamines

    L. Ma, X. Shi, X. Li and D. Shi, Org. Chem. Front., 2018, Advance Article , DOI: 10.1039/C8QO01028E

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