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Issue 21, 2018
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Dual photoredox and nickel-catalyzed desymmetric C–O coupling reactions: visible light-mediated enantioselective synthesis of 1,4-benzodioxanes

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Abstract

1,4-Benzodioxane widely exists as the core structure in many therapeutic agents and bioactive natural compounds. Hence, to access this kind of molecule, an enantioselective desymmetric C–O cross coupling reaction has been developed through dual visible light photoredox and nickel catalysis. Notably, the use of an axially chiral 2,2′-bipyridine ligand is the key to success. A series of chiral 1,4-benzodioxanes were afforded in high yields and moderate to good enantioselectivity under mild reaction conditions.

Graphical abstract: Dual photoredox and nickel-catalyzed desymmetric C–O coupling reactions: visible light-mediated enantioselective synthesis of 1,4-benzodioxanes

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Publication details

The article was received on 01 Aug 2018, accepted on 15 Sep 2018 and first published on 17 Sep 2018


Article type: Research Article
DOI: 10.1039/C8QO00805A
Citation: Org. Chem. Front., 2018,5, 3098-3102
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    Dual photoredox and nickel-catalyzed desymmetric C–O coupling reactions: visible light-mediated enantioselective synthesis of 1,4-benzodioxanes

    Q. Zhou, F. Lu, D. Liu, L. Lu and W. Xiao, Org. Chem. Front., 2018, 5, 3098
    DOI: 10.1039/C8QO00805A

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