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Issue 22, 2018
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Pd/Gorlos-Phos-catalyzed cross-coupling between two different aryl chlorides in the presence of B2Pin2 and cytotoxicity studies of the products

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Abstract

With the readily available Gorlos-Phos as a ligand, unsymmetrical biaryls were prepared efficiently from Pd-catalyzed one-pot two-step cross-coupling of two different aryl chlorides in the presence of B2Pin2, tolerating functional groups such as aldehyde, ketone, ester, ether, nitrile, amide, fluorine, sulphonyl and trifluoromethyl groups. Besides the substituted phenyl chlorides, hetero-aryl chlorides, 1-chloronaphthalene, and dichlorobenzenes could also be applied. The cytotoxicity against human lung cancer A549 cells for some of the compounds has been studied.

Graphical abstract: Pd/Gorlos-Phos-catalyzed cross-coupling between two different aryl chlorides in the presence of B2Pin2 and cytotoxicity studies of the products

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Publication details

The article was received on 28 Jul 2018, accepted on 11 Oct 2018 and first published on 11 Oct 2018


Article type: Research Article
DOI: 10.1039/C8QO00781K
Citation: Org. Chem. Front., 2018,5, 3319-3323
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    Pd/Gorlos-Phos-catalyzed cross-coupling between two different aryl chlorides in the presence of B2Pin2 and cytotoxicity studies of the products

    X. Duan, P. Li, G. Zhu, C. Fu, Q. Chen, X. Huang and S. Ma, Org. Chem. Front., 2018, 5, 3319
    DOI: 10.1039/C8QO00781K

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