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Issue 16, 2018
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Copper-catalyzed oxidative functionalization of benzylic C–H bonds with quinazoline 3-oxides

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Abstract

A highly efficient copper-catalyzed oxidative functionalization of benzylic C(sp3)–H bonds with quinazoline 3-oxides was described. This protocol provides a broad range of quinazolin-4(3H)-one derivatives in good to excellent yields using a Cu/TBHP oxidation system. A plausible reaction mechanism involving radical species is proposed to rationalize the experimental results.

Graphical abstract: Copper-catalyzed oxidative functionalization of benzylic C–H bonds with quinazoline 3-oxides

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Supplementary files

Article information


Submitted
13 Jun 2018
Accepted
11 Jul 2018
First published
12 Jul 2018

Org. Chem. Front., 2018,5, 2492-2495
Article type
Research Article

Copper-catalyzed oxidative functionalization of benzylic C–H bonds with quinazoline 3-oxides

L. Fan, Z. Zhang, T. Wang, Q. Liang and J. Zhao, Org. Chem. Front., 2018, 5, 2492
DOI: 10.1039/C8QO00588E

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