Issue 6, 2018

Copper-catalyzed peri-selective direct sulfenylation of 1-naphthylamines with disulfides

Abstract

A copper-catalyzed peri-selective direct C–H sulfenylation of 1-naphthylamines with disulfides was developed. This protocol employs inexpensive Cu(OAc)2 as the catalyst, air as the terminal oxidant, and readily available diaryl (or dialkyl) disulfide and diselenide as chalcogenation reagents. High functional group tolerance and excellent regioselectivity were demonstrated by the efficient preparation of a wide range of 8-sulfenyl-1-naphthylamines.

Graphical abstract: Copper-catalyzed peri-selective direct sulfenylation of 1-naphthylamines with disulfides

Supplementary files

Article information

Article type
Research Article
Submitted
11 Nov 2017
Accepted
30 Dec 2017
First published
03 Jan 2018

Org. Chem. Front., 2018,5, 982-989

Copper-catalyzed peri-selective direct sulfenylation of 1-naphthylamines with disulfides

Y. Xiong, Y. Yu, J. Weng and G. Lu, Org. Chem. Front., 2018, 5, 982 DOI: 10.1039/C7QO01016H

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