Issue 6, 2018
From the journal:

Organic Chemistry Frontiers

Synthesis of benzannulated spiroketals with gold-catalyzed cycloisomerization/spiroketalization cascade†

Qi Teng,a   Jialin Qi,a   Ling Zhou,b   Zhenghu Xu ORCID logo *ac  and  Chen-Ho Tunga  

* Corresponding authors

a Key Lab for Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, People's Republic of China
E-mail: xuzh@sdu.edu.cn

b Department of Chemistry and Biochemistry, Miami University, Oxford, OH, USA

c State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, PR China

Abstract

An unprecedented gold-catalyzed intramolecular cycloisomerization of alkynyl alcohol and intermolecular spiroketalization reaction with quinone monoimines has been successfully developed. By using this novel gold-catalyzed cascade, a variety of 5,5-benzannulated spiroketals were obtained from easily available starting materials under mild conditions.

Graphical abstract: Synthesis of benzannulated spiroketals with gold-catalyzed cycloisomerization/spiroketalization cascade

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Article information

DOI
https://doi.org/10.1039/C7QO01005B
Article type
Research Article
Submitted
07 Nov 2017
Accepted
22 Dec 2017
First published
25 Dec 2017

Org. Chem. Front., 2018,5, 990-993

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Synthesis of benzannulated spiroketals with gold-catalyzed cycloisomerization/spiroketalization cascade

Q. Teng, J. Qi, L. Zhou, Z. Xu and C. Tung, Org. Chem. Front., 2018, 5, 990 DOI: 10.1039/C7QO01005B

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