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Efficient synthesis of esters through oxone-catalyzed dehydrogenation of carboxylic acids and alcohols

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Abstract

Since esters are important organic synthesis intermediates, an environmentally friendly oxone catalyzed-esterification of carboxylic acids with alcohols has been developed. A series of carboxylic acid esters are obtained in high yield. This strategy requires mild reaction conditions, providing an attractive alternative for the construction of valuable carbonyl esters. Electron-rich and electron-deficient groups are compatible with the standard conditions and a variety of substrates are demonstrated. Moreover, the reaction could easily be adapted to typical prodrugs, drugs and gram-scale synthesis.

Graphical abstract: Efficient synthesis of esters through oxone-catalyzed dehydrogenation of carboxylic acids and alcohols

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Publication details

The article was received on 13 Oct 2018, accepted on 26 Nov 2018 and first published on 26 Nov 2018


Article type: Paper
DOI: 10.1039/C8OB02539H
Citation: Org. Biomol. Chem., 2018, Advance Article
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    Efficient synthesis of esters through oxone-catalyzed dehydrogenation of carboxylic acids and alcohols

    F. Hou, X. Wang and Z. Quan, Org. Biomol. Chem., 2018, Advance Article , DOI: 10.1039/C8OB02539H

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