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Issue 44, 2018
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A facile tandem decyanation/cyanation reaction of α-iminonitriles toward cyano-substituted amides

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Abstract

A new tandem decyanation/cyanation reaction of α-iminonitriles has been developed. A variety of cyano-substituted aryl amides and heteroaryl amides are synthesized in good yields. Both electron-rich and electron-deficient groups are compatible with the standard conditions. This reaction features a nonmetallic cyano source, tandem decyanation and cyanation reaction, waste utilization of the HCN from the hydrolysis of α-iminonitriles, formation of two important functional groups in one-step operation, etc.

Graphical abstract: A facile tandem decyanation/cyanation reaction of α-iminonitriles toward cyano-substituted amides

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Publication details

The article was received on 05 Sep 2018, accepted on 23 Oct 2018 and first published on 25 Oct 2018


Article type: Communication
DOI: 10.1039/C8OB02186D
Citation: Org. Biomol. Chem., 2018,16, 8481-8485
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    A facile tandem decyanation/cyanation reaction of α-iminonitriles toward cyano-substituted amides

    Z. Chen, P. Liang, B. Liu, H. Luo, J. Zheng, X. Wen, T. Liu and M. Ye, Org. Biomol. Chem., 2018, 16, 8481
    DOI: 10.1039/C8OB02186D

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