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Issue 46, 2018
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Synthesis of disaccharide nucleoside analogues as potential poly(ADP-ribose) polymerase-1 inhibitors

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Abstract

Poly(ADP-ribose) polymerase-1 (PARP-1) is an important target in cancer therapy. We present the synthesis of novel disaccharide nucleoside analogues that resemble the central motif of poly(ADP-ribose) and test their inhibitory effects on human PARP-1. Some compounds show inhibition of enzymatic activity in vitro and thus might be interesting for further investigations.

Graphical abstract: Synthesis of disaccharide nucleoside analogues as potential poly(ADP-ribose) polymerase-1 inhibitors

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Publication details

The article was received on 03 Aug 2018, accepted on 30 Aug 2018 and first published on 30 Aug 2018


Article type: Communication
DOI: 10.1039/C8OB01894D
Citation: Org. Biomol. Chem., 2018,16, 8904-8907
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    Synthesis of disaccharide nucleoside analogues as potential poly(ADP-ribose) polymerase-1 inhibitors

    M. Zheng, M. Mex, K. H. Götz and A. Marx, Org. Biomol. Chem., 2018, 16, 8904
    DOI: 10.1039/C8OB01894D

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