Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery†
We demonstrate a proof of principle for a new approach in the development of a drug delivery system. A positively charged prodrug (phenol) can form a stable inclusion complex with CB, which enables more efficient delivery of the prodrug. After photochemical transformation (photoactivation) inside the complex, an active drug quinone methide (QM) is formed and released from the complex, since it is a neutral molecule and forms a less stable complex with CB.
- This article is part of the themed collection: Supramolecular chemistry in OBC