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Issue 44, 2018
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The structural shift of a DNA template between a hairpin and a dimer tunes the emission color of DNA-templated AgNCs

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Abstract

The scaffolding DNA sequence and the size of silver nanoclusters (AgNCs), confined in a DNA template are the key parameters in determining the fluorescent properties of DNA-stabilized silver nanoclusters (DNA/AgNCs). In addition, we suggest here that the structural shift of a DNA hairpin-dimer is as important as the DNA sequence in determining the emission wavelength of DNA/AgNCs. Furthermore, we show that the structural shift post AgNC formation can be triggered by incubation time and pre-AgNC formation under salt conditions. As an important factor in predicting the emission properties of DNA/AgNCs, the modulation of DNA secondary structures with either sequence changes or ionic conditions can be applied for the dual-color detection system of a target molecule. Particularly, the dual-color detection method may increase the reliability of DNA/AgNC sensors for miRNAs.

Graphical abstract: The structural shift of a DNA template between a hairpin and a dimer tunes the emission color of DNA-templated AgNCs

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Publication details

The article was received on 01 Aug 2018, accepted on 11 Oct 2018 and first published on 12 Oct 2018


Article type: Paper
DOI: 10.1039/C8NR06186F
Citation: Nanoscale, 2018,10, 20717-20722
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    The structural shift of a DNA template between a hairpin and a dimer tunes the emission color of DNA-templated AgNCs

    P. Shah, S. W. Choi, R. Nagda, R. Geczy, S. K. Cho, Y. J. Bhang, T. Kim, T. Y. Song, P. H. Lee, J. Kang, P. W. Thulstrup, M. J. Bjerrum, I. L. Jung and S. W. Yang, Nanoscale, 2018, 10, 20717
    DOI: 10.1039/C8NR06186F

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