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Hexa-functional tumour-seeking nano voyagers and annihilators for synergistic cancer theranostic applications

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Abstract

In order to meet the unmet medical needs for effective cancer treatment, multifunctional nanocarriers based on iron oxide nanoparticles hold tremendous promise. Here we report a superparamagnetic iron oxide nanoparticles based hexa-functional nanosystem for synergistic cancer theranostic applications by offering active tumour targeting, accumulation and complementary imaging capability by combining magnetic resonance imaging as well as near-infrared fluorescence, magnetophotothermia and chemotherapy. The uniquely designed nanosystem exhibited a paramount increase in the antitumour efficacy through the simultaneous application of multiple thermal effects called magnetophotothermia, which outweighed the therapeutic efficacy of the current thermo-chemo therapies or stand-alone therapies. The active tumour-seeking property with prolonged tumour accumulation and complementary imaging capability with improved sensitivity and resolution also augments the therapeutic efficacy of the proposed nanosystem. Additionally, the work proposes a deep-learning-based tumour cell nuclei detection technique from H&E stained images in anticipation of providing much inspiration for the future of precision histology.

Graphical abstract: Hexa-functional tumour-seeking nano voyagers and annihilators for synergistic cancer theranostic applications

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Publication details

The article was received on 30 Jul 2018, accepted on 22 Sep 2018 and first published on 26 Sep 2018


Article type: Paper
DOI: 10.1039/C8NR06116E
Citation: Nanoscale, 2018, Advance Article
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    Hexa-functional tumour-seeking nano voyagers and annihilators for synergistic cancer theranostic applications

    A. Ramachandra Kurup Sasikala, A. R. Unnithan, R. G. Thomas, T. Batgerel, Y. Y. Jeong, C. H. Park and C. S. Kim, Nanoscale, 2018, Advance Article , DOI: 10.1039/C8NR06116E

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