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Issue 22, 2018
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Exploiting the biomolecular corona: pre-coating of nanoparticles enables controlled cellular interactions

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Abstract

Formation of the biomolecular corona ultimately determines the successful application of nanoparticles in vivo. Adsorption of biomolecules such as proteins is an inevitable process that takes place instantaneously upon contact with physiological fluid (e.g. blood). Therefore, strategies are needed to control this process in order to improve the properties of the nanoparticles and to allow targeted drug delivery. Here, we show that the design of the protein corona by a pre-formed protein corona with tailored properties enables targeted cellular interactions. Nanoparticles were pre-coated with immunoglobulin depleted plasma to create and design a protein corona that reduces cellular uptake by immune cells. It was proven that a pre-formed protein corona remains stable even after nanoparticles were re-introduced to plasma. This opens up the great potential to exploit protein corona formation, which will significantly influence the development of novel nanomaterials.

Graphical abstract: Exploiting the biomolecular corona: pre-coating of nanoparticles enables controlled cellular interactions

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Publication details

The article was received on 23 Apr 2018, accepted on 23 May 2018 and first published on 24 May 2018


Article type: Paper
DOI: 10.1039/C8NR03331E
Nanoscale, 2018,10, 10731-10739
  • Open access: Creative Commons BY license
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    Exploiting the biomolecular corona: pre-coating of nanoparticles enables controlled cellular interactions

    J. Simon, L. K. Müller, M. Kokkinopoulou, I. Lieberwirth, S. Morsbach, K. Landfester and V. Mailänder, Nanoscale, 2018, 10, 10731
    DOI: 10.1039/C8NR03331E

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