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Issue 1, 2018
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In-plane molecular organization of hydrated single lipid bilayers: DPPC:cholesterol

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Abstract

Understanding the physical properties of cholesterol–phospholipid systems is essential to gain a better knowledge of the function of each membrane constituent. We present a novel, simple and user-friendly setup that allows for the straightforward grazing incidence X-ray diffraction characterization of hydrated individual supported lipid bilayers. This configuration minimizes the scattering from the liquid and allows the detection of the extremely weak diffracted signal of the membrane, enabling the differentiation of the coexisting domains in DPPC:cholesterol single bilayers.

Graphical abstract: In-plane molecular organization of hydrated single lipid bilayers: DPPC:cholesterol

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Submitted
09 Oct 2017
Accepted
23 Nov 2017
First published
24 Nov 2017

Nanoscale, 2018,10, 87-92
Article type
Communication

In-plane molecular organization of hydrated single lipid bilayers: DPPC:cholesterol

B. Gumí-Audenis, L. Costa, L. Redondo-Morata, P. Milhiet, F. Sanz, R. Felici, M. I. Giannotti and F. Carlà, Nanoscale, 2018, 10, 87
DOI: 10.1039/C7NR07510C

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