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Pyridoxal phosphate-dependent reactions in the biosynthesis of natural products

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Abstract

Covering: up to mid-2018

Pyridoxal 5′-phosphate (PLP) is a versatile organic cofactor used to catalyze diverse reactions on amino acid, oxoacid, and amine substrates. Here we review the reactions catalyzed by PLP-dependent enzymes, highlighting enzymes reported in the natural product biosynthetic literature. We describe enzymes that catalyze transaminations, Claisen-like condensations, and β- and γ-eliminations and substitutions, along with epimerizations, decarboxylations, and transaldolations. Finally, we describe a newly reported group of O2-, PLP-dependent enzymes. Altogether, natural product biosynthesis showcases the incredible versatility of PLP-dependent transformations for building chemical complexity.

Graphical abstract: Pyridoxal phosphate-dependent reactions in the biosynthesis of natural products

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Publication details

The article was received on 04 Jun 2018 and first published on 05 Sep 2018


Article type: Review Article
DOI: 10.1039/C8NP00049B
Citation: Nat. Prod. Rep., 2018, Advance Article
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    Pyridoxal phosphate-dependent reactions in the biosynthesis of natural products

    Y. Du and K. S. Ryan, Nat. Prod. Rep., 2018, Advance Article , DOI: 10.1039/C8NP00049B

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