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Nonribosomal antibacterial peptides that target multidrug-resistant bacteria

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Abstract

Covering: 2000 to 2018, particularly from 2010 to early 2018

The increase in the incidence of antibiotic resistant infections is threatening to overwhelm healthcare practices worldwide. Most antibiotics in clinical use are becoming ineffective, so therefore it is imperative to develop new antibiotics and novel therapeutic strategies. Traditionally, the chemical and mechanistic diversity of nonribosomal antibacterial peptides (NRAPs) as lead compounds have meant that their structures are ideal for antibiotic discovery. Here, we summarize the state of our current knowledge about the mechanisms of antibiotic resistance, which can be used to guide the development of new antibiotics. Furthermore, we provide an overview of NRAPs for treating multi-drug resistant bacteria, including innovative approaches for screening NRAPs from new sources and the underlying mechanisms of antibacterial activity. Finally, we discuss the design of NRAP scaffolds for precise medicine and combinatorial NRAP therapies with existing antibiotics to overcome resistance, which will help to control infections in the post-antibiotic era.

Graphical abstract: Nonribosomal antibacterial peptides that target multidrug-resistant bacteria

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Publication details

The article was received on 02 Apr 2018 and first published on 16 Oct 2018


Article type: Review Article
DOI: 10.1039/C8NP00031J
Citation: Nat. Prod. Rep., 2018, Advance Article
  • Open access: Creative Commons BY-NC license
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    Nonribosomal antibacterial peptides that target multidrug-resistant bacteria

    Y. Liu, S. Ding, J. Shen and K. Zhu, Nat. Prod. Rep., 2018, Advance Article , DOI: 10.1039/C8NP00031J

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