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Metabolic functions of the human gut microbiota: the role of metalloenzymes

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Abstract

Covering: up to the end of 2017

The human body is composed of an equal number of human and microbial cells. While the microbial community inhabiting the human gastrointestinal tract plays an essential role in host health, these organisms have also been connected to various diseases. Yet, the gut microbial functions that modulate host biology are not well established. In this review, we describe metabolic functions of the human gut microbiota that involve metalloenzymes. These activities enable gut microbial colonization, mediate interactions with the host, and impact human health and disease. We highlight cases in which enzyme characterization has advanced our understanding of the gut microbiota and examples that illustrate the diverse ways in which metalloenzymes facilitate both essential and unique functions of this community. Finally, we analyze Human Microbiome Project sequencing datasets to assess the distribution of a prominent family of metalloenzymes in human-associated microbial communities, guiding future enzyme characterization efforts.

Graphical abstract: Metabolic functions of the human gut microbiota: the role of metalloenzymes

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Publication details

The article was received on 14 Aug 2018 and first published on 19 Nov 2018


Article type: Review Article
DOI: 10.1039/C8NP00074C
Citation: Nat. Prod. Rep., 2019, Advance Article
  • Open access: Creative Commons BY license
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    Metabolic functions of the human gut microbiota: the role of metalloenzymes

    L. J. Rajakovich and E. P. Balskus, Nat. Prod. Rep., 2019, Advance Article , DOI: 10.1039/C8NP00074C

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