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Issue 23, 2018
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Naked-eye and ratiometric fluorescence probe for fast and sensitive detection of hydrogen sulfide and its application in bioimaging

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Abstract

Hydrogen sulfide (H2S) is a remarkable endogenous gasotransmitter involved in numerous biological processes, and its noninvasive, rapid and accurate measurement in living cells and animals is urgently needed. Herein, we report a ratiometric fluorescent H2S-specific probe (CyT). This new probe can be readily prepared by modifying the triflate group (CF3SO3) into hemicyanine, and it shows excellent sensing properties. First, CyT is highly selective against other biologically relevant anions, cations, reactive sulfur and small molecules; meanwhile, it has a low limit of detection (LOD) to H2S (7.33 nM) In addition, CyT exhibits rapid response to H2S (rate constant is 1464 M−1 s−1) and apparent color change from dark blue to very pale green, which is observed with the naked-eye. Furthermore, it exhibits low cytotoxicity to HeLa cells and can be successfully used for the detection of H2S activity in cells and zebrafish.

Graphical abstract: Naked-eye and ratiometric fluorescence probe for fast and sensitive detection of hydrogen sulfide and its application in bioimaging

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Publication details

The article was received on 19 Aug 2018, accepted on 26 Sep 2018 and first published on 26 Sep 2018


Article type: Paper
DOI: 10.1039/C8NJ04208J
Citation: New J. Chem., 2018,42, 19272-19278
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    Naked-eye and ratiometric fluorescence probe for fast and sensitive detection of hydrogen sulfide and its application in bioimaging

    J. Ma, F. Li, Q. Li, Y. Li, C. Yan, X. Lu and Y. Guo, New J. Chem., 2018, 42, 19272
    DOI: 10.1039/C8NJ04208J

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