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Naked-eye and ratiometric fluorescence probe for fast and sensitive detection of hydrogen sulfide and its application in bioimaging

Abstract

As an exciting endogenous gasotransmitter involved in numerous biological processes, the noninvasive, rapid and accurate measurement for hydrogen sulfide (H2S) in living cells and animals is urgently demanded. Herein, we developed a ratiometric fluorescent H2S -specific probe (CyT). This new probe can be readily prepared by modifying triflate group (CF3SO3-) into hemicyanine and shows excellent sensing properties. First of all, CyT shows highly selective against other biological relevant anions, cations, reactive sulfur and small molecules. Meanwhile, it has a low limit of detection (LOD) to H2S as 7.33 nM. In addition, CyT exhibits rapid response to H2S (rate constant as 1464 M-1s-1) and apparent color change from dark blue to very pale green was observed with naked-eye. Furthermore, it has low cytotoxicity to Hela cells and can successfully apply to detecting H2S activity in cells and zebrafish.

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Publication details

The article was received on 19 Aug 2018, accepted on 26 Sep 2018 and first published on 26 Sep 2018


Article type: Paper
DOI: 10.1039/C8NJ04208J
Citation: New J. Chem., 2018, Accepted Manuscript
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    Naked-eye and ratiometric fluorescence probe for fast and sensitive detection of hydrogen sulfide and its application in bioimaging

    J. Ma, F. Li, Q. Li, Y. Li, C. Yan, X. Lu and Y. Guo, New J. Chem., 2018, Accepted Manuscript , DOI: 10.1039/C8NJ04208J

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