* Corresponding authors

^a Department of Orthopedics, The First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, 708 Renmin Road, Suzhou, Jiangsu 215006, P. R. China
E-mail: shiqin@suda.edu.cn

^b Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, P. R. China
E-mail: wgcui80@hotmail.com

^c State Key Laboratory of Molecular Engineering of Polymers, Fudan University, No. 220 Handan Road, Shanghai 200433, P. R. China

^d Animal Experimental Center, Soochow University, 99 Renai Road, Suzhou, Jiangsu, P. R. China

^e Department of Pharmaceutical Sciences Laboratory, Åbo Akademi University, Finland

^f Turku Center for Biotechnology, University of Turku and Åbo Akademi University, Finland

^g Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki FI-00014, Finland

^h Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki FI-00014, Finland
E-mail: helder.santos@helsinki.fi

ⁱ Department of Medicine, James Graham Brown Cancer Center, University of Louisville, 505 South Hancock Street, Louisville, USA

^j Key Laboratory of Stem Cells and Biomedical Materials of Jiangsu Province and Chinese Ministry of Science and Technology, 199 Renai Rd, Suzhou, China