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Issue 20, 2018
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Controlled photo-flow oxidative reaction (UV-FOR) platform for ultra-fast phthalide and API synthesis

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Abstract

An integrated photo-flow oxidative reaction (UV-FOR) platform approach is presented for the synthesis of phthalides. The current protocol is catalyst-free, and uses economical and abundant hydro-carbons and hydrocarbon derivatives such as benzoic acid, benzene, and xylene, as starting materials. The reaction is performed using oxygen as a green oxidant in a time- and labour-efficient manner. This integrated approach has been shown to be successful in making a UV-FOR platform suitable for the on-demand synthesis of phthalides and their further syntheses to 2-arylmethylbenzoic acids and arylogous Michael addition products under relatively mild conditions. The current protocol was further extended to the gram scale synthesis of an ischemic stroke-relevant active pharmaceutical ingredient (API), 3-N-butylphthalide (NBP), in a continuous flow process.

Graphical abstract: Controlled photo-flow oxidative reaction (UV-FOR) platform for ultra-fast phthalide and API synthesis

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Publication details

The article was received on 25 Jul 2018, accepted on 12 Sep 2018 and first published on 12 Sep 2018


Article type: Communication
DOI: 10.1039/C8GC02320D
Citation: Green Chem., 2018,20, 4584-4590
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    Controlled photo-flow oxidative reaction (UV-FOR) platform for ultra-fast phthalide and API synthesis

    D. Aand, S. Karekar, B. Mahajan, A. B. Pawar and A. K. Singh, Green Chem., 2018, 20, 4584
    DOI: 10.1039/C8GC02320D

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