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Catalyst-free three-component sequencing for efficient assembly of [1,3] oxazine N-fused imidazole-2-thiones

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Abstract

A one-pot, catalyst-free, three-component sequential double-annulation from amine alcohols, glyoxal monohydrates and KSCN underwent imine formation/intramolecular cyclization/[3 + 2] cycloaddition. This tandem and green reaction offered [1,3] oxazine N-fused imidazole-2-thiones in a mild condition, with a very short reaction time, wide variation in functional groups, high efficacy on the gram-large scale and followed group-assisted purification chemistry work-up.

Graphical abstract: Catalyst-free three-component sequencing for efficient assembly of [1,3] oxazine N-fused imidazole-2-thiones

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Publication details

The article was received on 05 Jun 2018, accepted on 04 Jul 2018 and first published on 04 Jul 2018


Article type: Communication
DOI: 10.1039/C8GC01766B
Citation: Green Chem., 2018, Advance Article
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    Catalyst-free three-component sequencing for efficient assembly of [1,3] oxazine N-fused imidazole-2-thiones

    E. Chen, J. Shao, P. Tang, K. Shu, W. Chen and Y. Yu, Green Chem., 2018, Advance Article , DOI: 10.1039/C8GC01766B

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