Issue 16, 2018
From the journal:

Green Chemistry

Catalyst and solvent free microwave-assisted synthesis of substituted 1,2,3-triazoles†

Sahar Roshandel,a   Suresh C. Suri,*a   Jacob C. Marcischak,b   Golam Rasula  and  G. K. Surya Prakash ORCID logo *a  

* Corresponding authors

a Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, CA, USA
E-mail: gprakash@usc.edu, sureshsuri52@gmail.com

b Air Force Research Laboratory/Rocket Propulsion Division, Edwards Airforce Base, CA, USA

Abstract

We report a microwave-assisted catalyst and solvent free synthesis of 1,2,3-triazoles through the cycloaddition of trimethylsilylazide and acetylenes. Utilization of a thermally stable azide source, elimination of a metal catalyst, solvent or any additives, and a convenient isolation procedure result in an overall greener approach to access 1,2,3-triazoles on a practical scale with good to excellent yields (55–99%).

Graphical abstract: Catalyst and solvent free microwave-assisted synthesis of substituted 1,2,3-triazoles

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Article information

DOI
https://doi.org/10.1039/C8GC01516C
Article type
Communication
Submitted
16 May 2018
Accepted
11 Jul 2018
First published
20 Jul 2018

Green Chem., 2018,20, 3700-3704

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Catalyst and solvent free microwave-assisted synthesis of substituted 1,2,3-triazoles

S. Roshandel, S. C. Suri, J. C. Marcischak, G. Rasul and G. K. Surya Prakash, Green Chem., 2018, 20, 3700 DOI: 10.1039/C8GC01516C

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