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Visible-light driven regioselective synthesis of 1H-tetrazoles from aldehydes through isocyanide-based [3 + 2] cycloaddition

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Abstract

A novel and green Co@g-C3N4 catalyzed visible light driven direct regioselective synthesis of 1H-tetrazoles directly from various aldehydes and sodium azide is reported. Herein, NaN3 not only behaves as a three-nitrogen donor of the tetrazole ring but also it converts aldehyde into isocyanide as a one-nitrogen source. The regioselectivity of the product, operational simplicity, ambient reaction conditions, no use of column chromatography for purification, excellent yield of products (84–95%) and recyclability of the catalyst up to five times without any substantial change in the morphology and catalytic efficiency are the salient features of the envisaged protocol.

Graphical abstract: Visible-light driven regioselective synthesis of 1H-tetrazoles from aldehydes through isocyanide-based [3 + 2] cycloaddition

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Publication details

The article was received on 26 Apr 2018, accepted on 06 Jul 2018 and first published on 12 Jul 2018


Article type: Paper
DOI: 10.1039/C8GC01321G
Citation: Green Chem., 2018, Advance Article
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    Visible-light driven regioselective synthesis of 1H-tetrazoles from aldehydes through isocyanide-based [3 + 2] cycloaddition

    F. Verma, A. Sahu, P. K. Singh, A. Rai, M. Singh and V. K. Rai, Green Chem., 2018, Advance Article , DOI: 10.1039/C8GC01321G

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