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Issue 21, 2018
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Radicals in natural product synthesis

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Free radical intermediates have intrigued chemists since their discovery, and an ever-increasing appreciation for their unique reactivity has resulted in the widespread utilization of these species throughout the field of chemical synthesis. This is most evident from the recent surge in the application of intermolecular radical reactions that feature in complex molecule syntheses. This tutorial review will discuss the diverse methods utilized for radical generation and reactivity to form critical bonds in natural product total synthesis. In particular, stabilized (e.g. benzyl) and persistent (e.g. TEMPO) radicals will be the primary focus.

Graphical abstract: Radicals in natural product synthesis

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Article information

09 May 2018
First published
13 Aug 2018

Chem. Soc. Rev., 2018,47, 7851-7866
Article type
Tutorial Review
Author version available

Radicals in natural product synthesis

K. J. Romero, M. S. Galliher, D. A. Pratt and C. R. J. Stephenson, Chem. Soc. Rev., 2018, 47, 7851
DOI: 10.1039/C8CS00379C

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