Issue 89, 2018

Efficient synthesis of 2-arylquinazolin-4-amines via a copper-catalyzed diazidation and ring expansion cascade of 2-arylindoles

Abstract

Copper-catalyzed synthesis of 2-arylquinazolin-4-amines from readily available 2-arylindoles and TMSN3 has been developed. The mechanism study shows that the domino reaction may involve a free radical diazidation, denitrogenation, intramolecular cyclization and ring expansion sequence.

Graphical abstract: Efficient synthesis of 2-arylquinazolin-4-amines via a copper-catalyzed diazidation and ring expansion cascade of 2-arylindoles

Supplementary files

Article information

Article type
Communication
Submitted
26 Sep 2018
Accepted
12 Oct 2018
First published
15 Oct 2018

Chem. Commun., 2018,54, 12602-12605

Efficient synthesis of 2-arylquinazolin-4-amines via a copper-catalyzed diazidation and ring expansion cascade of 2-arylindoles

M. Xu, W. Cao, X. Xu and S. Ji, Chem. Commun., 2018, 54, 12602 DOI: 10.1039/C8CC07721E

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