An integrated nanocatalyst combining enzymatic and metal–organic framework catalysts for cascade degradation of organophosphate nerve agents

Abstract

An integrated nanocatalyst (INC), denoted OPH@MIL-100(Fe), was synthesized by immobilizing a biocatalyst onto a metal–organic framework (MOF)-based catalyst, which can cascadingly degrade organophosphate nerve agents to 4-aminophenol (4-AP) and result in a sharp decrease of their toxicity up to 208-fold.