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Issue 76, 2018
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Sydnone-coumarins as clickable turn-on fluorescent sensors for molecular imaging

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Abstract

Copper-catalyzed and copper-free sydnone–alkyne cycloaddition reactions have emerged as complementary click tools for chemical biology but their use in bioorthogonal labeling is still in its infancy. Herein, combinations of alkynes and coumarin-sydnones were screened for their ability to generate pyrazole products displaying strong fluoroscence enhancement compared to reactants. One sydnone was identified as a particularly suitable new turn-on probe for protein labeling.

Graphical abstract: Sydnone-coumarins as clickable turn-on fluorescent sensors for molecular imaging

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Publication details

The article was received on 26 Jul 2018, accepted on 31 Aug 2018 and first published on 03 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC06070C
Citation: Chem. Commun., 2018,54, 10758-10761
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    Sydnone-coumarins as clickable turn-on fluorescent sensors for molecular imaging

    E. Decuypère, M. Riomet, A. Sallustrau, S. Bregant, R. Thai, G. Pieters, G. Clavier, D. Audisio and F. Taran, Chem. Commun., 2018, 54, 10758
    DOI: 10.1039/C8CC06070C

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