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A facile route to 1H- and 2H-indazoles from readily accessible acyl hydrazides by exploiting a novel aryne-based molecular rearrangement

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Abstract

Herein we report the transformation of readily synthesised acyl hydrazides into 2-hydrazobenzophenones via a novel molecular rearrangement pathway using aryne chemistry. The developed reaction protocol is performed under relatively mild conditions and is tolerant of a wide variety of functional groups, and the 2-hydrazobenzophenone products provide access to both 1H- and 2H-indazoles from a single intermediate.

Graphical abstract: A facile route to 1H- and 2H-indazoles from readily accessible acyl hydrazides by exploiting a novel aryne-based molecular rearrangement

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Publication details

The article was received on 11 Aug 2018, accepted on 11 Sep 2018 and first published on 11 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC06556J
Citation: Chem. Commun., 2018, Advance Article
  • Open access: Creative Commons BY license
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    A facile route to 1H- and 2H-indazoles from readily accessible acyl hydrazides by exploiting a novel aryne-based molecular rearrangement

    A. Shamsabadi and V. Chudasama, Chem. Commun., 2018, Advance Article , DOI: 10.1039/C8CC06556J

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