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Issue 84, 2018
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A sequence environment modulates the impact of methylation on the torsional rigidity of DNA

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Abstract

We describe a potential molecular mechanism explaining how DNA methylation contributes to biological regulation. Using molecular dynamics together with a new torsional restraint, we identify the impact of methylation on DNA response to torsional stress. We observe that, depending on the sequence, DNA methylation hinders overwinding or underwinding molecular transitions.

Graphical abstract: A sequence environment modulates the impact of methylation on the torsional rigidity of DNA

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Publication details

The article was received on 11 Aug 2018, accepted on 28 Sep 2018 and first published on 28 Sep 2018


Article type: Communication
DOI: 10.1039/C8CC06550K
Citation: Chem. Commun., 2018,54, 11885-11888
  • Open access: Creative Commons BY license
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    A sequence environment modulates the impact of methylation on the torsional rigidity of DNA

    J. Hörberg and A. Reymer, Chem. Commun., 2018, 54, 11885
    DOI: 10.1039/C8CC06550K

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