Issue 84, 2018

Arylation of benzyl amines with aromatic nitriles

Abstract

In the past years, the activations of aromatic nitriles for radical arylations under photoirradiation have been developed. We here report the first example of radical arylations using aromatic nitriles without the assistance of photoirradiation. Importantly, with this method, the direct arylation of C(sp3)–H in benzyl amines provided a practical method for the synthesis of diarylmethylamines without the use of precious transition metal catalysts.

Graphical abstract: Arylation of benzyl amines with aromatic nitriles

Supplementary files

Article information

Article type
Communication
Submitted
06 Aug 2018
Accepted
24 Sep 2018
First published
25 Sep 2018

Chem. Commun., 2018,54, 11881-11884

Arylation of benzyl amines with aromatic nitriles

Y. Lei, J. Yang, R. Qi, S. Wang, R. Wang and Z. Xu, Chem. Commun., 2018, 54, 11881 DOI: 10.1039/C8CC06408C

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