Cu transfer from amyloid-β4–16 to metallothionein-3: the role of the neurotransmitter glutamate and metallothionein-3 Zn(II)-load states

Alice Santoro; Nina Ewa Wezynfeld; Ewelina Stefaniak; Adam Pomorski; Dawid Płonka; Artur Krężel; Wojciech Bal; Peter Faller

doi:10.1039/C8CC06221H

You do not have JavaScript enabled. Please enable JavaScript to access the full features of the site or access our non-JavaScript page.

Cu transfer from amyloid-β_4–16 to metallothionein-3: the role of the neurotransmitter glutamate and metallothionein-3 Zn(ii)-load states†

Alice Santoro,^a Nina Ewa Wezynfeld,^ab Ewelina Stefaniak,^b Adam Pomorski,

^c Dawid Płonka,^b Artur Krężel,

*^c Wojciech Bal

*^b and Peter Faller

*^a

Author affiliations

* Corresponding authors

^a Institut de Chimie, UMR 7177, CNRS-Université de Strasbourg, 4 rue Blaise Pascal, Strasbourg, France
E-mail: pfaller@unistra.fr

^b Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106 Warsaw, Poland
E-mail: wbal@ibb.waw.pl

^c Department of Chemical Biology, Faculty of Biotechnology, University of Wrocław, F. joliot-Curie 14a, Wrocław, Poland
E-mail: artur.krezel@uwr.edu.pl

Abstract

Copper transfer from Cu(II)amyloid-β_4–16 to human Zn₇-metallothionein-3 can be accelerated by glutamate and by lowering the Zn-load of metallothionein-3 with EDTA. Glutamate facilitates the Cu(II) release, and Zn_4–6-metallothionein-3 react more rapidly. These mechanisms are additive, proving the intricate and interconnected network of zinc and copper trafficking between biomolecules.

Download options Please wait...

Supplementary files

Supplementary information PDF (2309K)

Article information

DOI: https://doi.org/10.1039/C8CC06221H
Article type: Communication
Submitted: 31 Jul 2018
Accepted: 15 Oct 2018
First published: 17 Oct 2018

Download Citation

Chem. Commun., 2018,54, 12634-12637

Permissions

Request permissions

Cu transfer from amyloid-β_4–16 to metallothionein-3: the role of the neurotransmitter glutamate and metallothionein-3 Zn(II)-load states

A. Santoro, N. E. Wezynfeld, E. Stefaniak, A. Pomorski, D. Płonka, A. Krężel, W. Bal and P. Faller, Chem. Commun., 2018, 54, 12634 DOI: 10.1039/C8CC06221H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Social activity

Fetching data from CrossRef.
This may take some time to load.

Chemical Communications