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Issue 62, 2018
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Flow chemistry-enabled studies of rhodium-catalyzed hydroformylation reactions

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Abstract

We present an automated microscale flow chemistry platform for rapid performance evaluation of continuous and discrete reaction parameters in homogeneous hydroformylation reactions. We demonstrate the versatility of the developed microfluidic platform through a systematic study of the effects of a library of phosphine-based ligands on catalytic activity and regioselectivity.

Graphical abstract: Flow chemistry-enabled studies of rhodium-catalyzed hydroformylation reactions

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Publication details

The article was received on 12 Jun 2018, accepted on 03 Jul 2018 and first published on 03 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC04650F
Chem. Commun., 2018,54, 8567-8570

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    Flow chemistry-enabled studies of rhodium-catalyzed hydroformylation reactions

    C. Zhu, K. Raghuvanshi, C. W. Coley, D. Mason, J. Rodgers, M. E. Janka and M. Abolhasani, Chem. Commun., 2018, 54, 8567
    DOI: 10.1039/C8CC04650F

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