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Issue 62, 2018
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Flow chemistry-enabled studies of rhodium-catalyzed hydroformylation reactions

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Abstract

We present an automated microscale flow chemistry platform for rapid performance evaluation of continuous and discrete reaction parameters in homogeneous hydroformylation reactions. We demonstrate the versatility of the developed microfluidic platform through a systematic study of the effects of a library of phosphine-based ligands on catalytic activity and regioselectivity.

Graphical abstract: Flow chemistry-enabled studies of rhodium-catalyzed hydroformylation reactions

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Article information


Submitted
12 Jun 2018
Accepted
03 Jul 2018
First published
03 Jul 2018

Chem. Commun., 2018,54, 8567-8570
Article type
Communication

Flow chemistry-enabled studies of rhodium-catalyzed hydroformylation reactions

C. Zhu, K. Raghuvanshi, C. W. Coley, D. Mason, J. Rodgers, M. E. Janka and M. Abolhasani, Chem. Commun., 2018, 54, 8567
DOI: 10.1039/C8CC04650F

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