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A combination of the Mitsunobu reaction and Glaser coupling was used to achieve a new glycoazobenzene macrocycle. This photosensitive macrocycle can be efficiently and reversibly switched between two stable conformational isomers, which are characterized with photoswitchable shape, chiroptical and solubility behaviour.

Graphical abstract: A two-step approach to a glycoazobenzene macrocycle with remarkable photoswitchable features

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