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Issue 66, 2018
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Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses

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Abstract

We present a chemical methylome analysis platform to evaluate the inhibitory activity of small molecules towards poorly characterized protein methyltransferases (PMTs), facsilitating to identify syn-HyPA-ETP-2 as a non-histone arginine methyltransferase inhibitor.

Graphical abstract: Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses

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Publication details

The article was received on 16 May 2018, accepted on 23 Jul 2018 and first published on 31 Jul 2018


Article type: Communication
DOI: 10.1039/C8CC03907K
Citation: Chem. Commun., 2018,54, 9202-9205
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    Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses

    Y. Sohtome, T. Shimazu, J. Barjau, S. Fujishiro, M. Akakabe, N. Terayama, K. Dodo, A. Ito, M. Yoshida, Y. Shinkai and M. Sodeoka, Chem. Commun., 2018, 54, 9202
    DOI: 10.1039/C8CC03907K

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